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i am not python permanent user how to run python script by click event from visual studio 2012.

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You could execute any Python implementation as a child process using command line arguments, stdin, stdout, even sockets etc. to communicate.

Alternatively if you want one process but not IronPython you could use the C-API for CPython (python.org) with PInvoke or some native code. You can either embed it in your process or you could make your C# into a module (extending).

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