TLDR: Today, no.
In the future yes, but it will require some additional work from the typescript team and from the Angular team.
Long Answer:
Angular builds applications with its own compiler called "NGC". NGC is a typescript programm (ts.Program) that basically wraps the typescript compiler.
NGC does call the typescript compiler APIs directly, not via the tsc command line.
Now that the typescript compiler is going native, this is no longer directly possible. It will require some additionnal work on both the Typescript team side and the Angular team side.
- Typescript will need to expose IPCs to allow typescript programms like NGC to invoke the TSGo compiler from a node environment
- Angular will need to refactor its compiler to adapt to those changes. The amount of work this represents today is unknown, as we don't know how many of today's TS APIs will be accessible via the promised IPCs.