Conditional RequireJs configuration (Load requirejs-config.js programmatically?)

Based on @Arshad M comment, you can add a di.xml with:

    <?xml version="1.0"?>
<config xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
        xsi:noNamespaceSchemaLocation="urn:magento:framework:ObjectManager/etc/config.xsd">

    <preference for="Magento\Framework\RequireJs\Config" type="<Vendor>\<ModuleName>\RequireJs\Config"/>

</config>

And in < Vendor >\< ModuleName >\RequireJs\Config.php override the getConfig function adding your condition and the module name that you don't want the requirejs to be loaded (probably from ScopeConfigInterface) :

   <?php

namespace <Vendor>\<ModuleName>\RequireJs;

use Magento\Framework\Filesystem\File\ReadFactory;
use Magento\Framework\View\Asset\Minification;
use Magento\Framework\View\Asset\RepositoryMap;

class Config extends \Magento\Framework\RequireJs\Config
{
    /**
     * @var \Magento\Framework\RequireJs\Config\File\Collector\Aggregated
     */
    private $fileSource;
    /**
     * @var ReadFactory
     */
    private $readFactory;
    /**
     * @var \Magento\Framework\Code\Minifier\AdapterInterface
     */
    private $minifyAdapter;
    /**
     * @var Minification
     */
    private $minification;
    /**
     * @var \Magento\Framework\View\DesignInterface
     */
    private $design;

    public function __construct(\Magento\Framework\RequireJs\Config\File\Collector\Aggregated $fileSource, \Magento\Framework\View\DesignInterface $design, ReadFactory $readFactory, \Magento\Framework\View\Asset\Repository $assetRepo, \Magento\Framework\Code\Minifier\AdapterInterface $minifyAdapter, Minification $minification, RepositoryMap $repositoryMap)
    {
        parent::__construct($fileSource, $design, $readFactory, $assetRepo, $minifyAdapter, $minification, $repositoryMap);
        $this->fileSource = $fileSource;
        $this->readFactory = $readFactory;
        $this->minifyAdapter = $minifyAdapter;
        $this->minification = $minification;
        $this->design = $design;
    }

    public function getConfig()
    {
        $distributedConfig = '';
        $customConfigFiles = $this->fileSource->getFiles($this->design->getDesignTheme(), self::CONFIG_FILE_NAME);
        foreach ($customConfigFiles as $file) {
            //Your condition
            if(true){
                if($file->getModule() == "Vendor_ModuleName"){
                    continue;
                }
            }

            /** @var $fileReader \Magento\Framework\Filesystem\File\Read */
            $fileReader = $this->readFactory->create($file->getFileName(), \Magento\Framework\Filesystem\DriverPool::FILE);
            $config = $fileReader->readAll($file->getName());


            $distributedConfig .= str_replace(
                ['%config%', '%context%'],
                [$config, $file->getModule()],
                self::PARTIAL_CONFIG_TEMPLATE
            );
        }

        $fullConfig = str_replace(
            ['%function%', '%usages%'],
            [$distributedConfig],
            self::FULL_CONFIG_TEMPLATE
        );


        if ($this->minification->isEnabled('js')) {
            $fullConfig = $this->minifyAdapter->minify($fullConfig);
        }

        return $fullConfig;
    }
}

UPDATE

After comments from @Alex and @Daniel: You can make an after plugin for getFiles from Magento\Framework\RequireJs\Config\File\Collector\Aggregated , so the new di.xml with this approach would be:

 <?xml version="1.0"?>
<config xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
        xsi:noNamespaceSchemaLocation="urn:magento:framework:ObjectManager/etc/config.xsd">

    <type name="Magento\Framework\RequireJs\Config\File\Collector\Aggregated">
        <plugin name="requirejsConfigPlugin"
                type="<Vendor>\<ModuleName>\Plugin\RequireJs\AfterFiles"
                sortOrder="100"
        />
    </type>
</config>

And at \< Vendor>\< ModuleName>\Plugin\RequireJs\AfterFiles, you can set your condition and module that the requirejs will not be load:

<?php

namespace <Vendor>\<ModuleName>\Plugin\RequireJs;

class AfterFiles
{
    public function afterGetFiles(
        \Magento\Framework\RequireJs\Config\File\Collector\Aggregated $subject,
        $result
    ){
        //Your condition
        if(true) {
            foreach ($result as $key => &$file) {
                //Module to exclude
                if ($file->getModule() == "Vendor_OtherModuleName") {
                    unset($result[$key]);
                }
            }
        }
        return $result;
    }
}