Assorted additions to the existing answers:
The Robocom BitStik CAD system required a 6502 second processor, as a basic BBC micro didn't have enough RAM: it had originally been written in assembler for the 48KB Apple ][. It was fairly sophisticated for CAD on an 8-bit system, but being written in assembler meant it quickly became obsolete. There was also an enhanced version of the original BBC Micro Elite that required a 6502 second processor, and could be played with the BitStik 3-axis joystick. That joystick plugged into the ordinary BBC joystick port, using three of its four A-D channels for the three axes. The Apple ][ version of the Bitstik was mechanically the same, but had different electronics and connectors to fit the Apple ][ joystick port.
Panos was pretty simple. It was basically intended for running compilers and scientific programs on the NS32016, but the Acorn-influenced world gave up on 32016 in favour of ARMs, which were faster, cheaper and simpler.